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Organic cation/carnitine transporter

WitrynaL-Carnitine and ALCAR are absorbed in the intestines (jejunum) mostly by the organic cation transporter 2 (OCTN2)[50][51] which is a sodium dependent transporter.[39] This transporters takes up L-carnitine molecules, and while ALCAR needs to be deacetylated (removal of the acetyl group) prior to absorption it can readily be … WitrynaCarnitine/organic cation transporter (OCTN) 2 (SLC22A5) plays a pivotal role in renal tubular reabsorption of carnitine, a vitamin-like compound, on apical membranes of …

Organic Cation Transporter 2 - an overview ScienceDirect Topics

Witryna8 godz. temu · Organic cation transporter 2 (OCT2) is mainly responsible for the renal secretion of various cationic drugs, closely associated with drug-induced acute kidney injury (AKI). Screening and identifying potent OCT2 inhibitors with little toxicity in natural products in reducing OCT2-mediated AKI is of great value. Flavonoids are enriched in … WitrynaSeveral SLC22 transporters in the human kidney and other tissues are thought to regulate endogenous small antioxidant molecules such as uric acid, ergothioneine, … tema lomba 17 agustus yang menarik https://marinchak.com

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WitrynaDive into the research topics of 'Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1'. Together they form a unique fingerprint. Ergothioneine Medicine & Life Sciences 100% Witryna26 mar 2013 · Major functional clusters for Up-Ex RAGs were glycosaminoglycan binding, cell migration, inorganic cation hemostasis, regulation of phosphorylation, regulation of apoptosis. Down-Nd RAGs were found in the clusters annotated as calcium binding region, domain EF hand, and mitosis. WitrynaAmong these molecules, carnitine is an endogenous amine which is an essential cofactor for mitochondrial beta-oxidation. Recently, a new family of transporters, … tema lokakarya

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Organic cation/carnitine transporter

Organic Cation Transporter 2 - an overview ScienceDirect Topics

WitrynaSpecies specificity profiling of rat and human organic cation/carnitine transporter Slc22a5/SLC22A5 (Octn2/OCTN2) Author links open overlay panel Kitti Szabó a b , Zoltán Nagy a 1 , Viktória Juhász a , Joseph K. Zolnerciks b , Attila Csorba b 2 , Zoltán Tímár b , Éva Molnár b , Petra Pádár b , William Johnson a , Erzsébet Beéry a ... WitrynaOne of the compounds necessary in the process of mitochondrial β-oxidation and export of acyl moieties from peroxisomes is l-carnitine. Two Na-dependent plasma membrane carnitine transporters were shown previously to be present in astrocytes: a low affinity amino acid transporter B0,+ and a high affinity cation/carnitine transporter OCTN2.

Organic cation/carnitine transporter

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Witryna27 kwi 2024 · Carnitine/organic cation transporter 1 (OCTN1) is the only known uptake transporter for ergothioneine which is a food-derived strong antioxidant amino … Witryna1 gru 2024 · Non-labeled colistin inhibited the OCTN2-mediated transport of [3H]L-carnitine in a non-competitive manner and that of [14C]tetraethylammonium bromide ([ 14C]TEA) in a competitive manner, suggesting that colistsin toxicity occurred upon intracellular accumulation. Colistin is a polycation antibiotic used for the treatment of …

Witryna1 lip 2002 · Abstract. l-Carnitine must be transported against a substantial concentration gradient across the epididymal epithelium to achieve high intraluminal levels, … WitrynaIntroduction: Organic cation transporters collectively called OCTs belong to three gene families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 OCTN2, SLC29A4 PMAT, SLC47A1 MATE1...

WitrynaPTHR24064:SF530 ORGANIC CATION/CARNITINE TRANSPORTER 4 1 hit; PTHR24064 SOLUTE CARRIER FAMILY 22 MEMBER 1 hit; PROSITE. View protein … Witryna20 cze 2003 · Spermatozoan maturation, motility, and fertility are, in part, dependent upon the progressive increase in epididymal and spermatozoal carnitine, critical for …

WitrynaGene ID: 123122744, updated on 24-Aug-2024. Summary Other designations. organic cation/carnitine transporter 7-like

WitrynaOrganic cation/carnitine transporters transport carnitine, drugs, and xenobiotics (e.g. choline, acetylcarnitine, betaine, valproic acid), and are expressed in muscle, heart, … tema logo hari kebangsaan 2022WitrynaIt has been reported that organic cation/carnitine transporter 1 (OCTN1) is associated with rheumatoid arthritis and Crohn's disease. Additionally, we reported that OCTN1 … tema lomba bisnis planWitrynaOrganic Cation Transporter 2. Furthermore, the organic cation transporter 2 (OCT2) has been shown to be implicated in cisplatin transport mainly in the intestine, … tema lomba daiWitryna1 dzień temu · Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter. Pflugers Arch. 2013; 465:1701–1714. doi: 10.1007/s00424-013-1307-z Crossref Medline Google Scholar; 81. Koepsell H. The SLC22 family with transporters of organic cations, anions and … tema logo merdeka 2022Witryna14 lip 2006 · Carnitine is a zwitterion essential for the {beta}-oxidation of fatty acids. We report novel localization of the organic cation/carnitine transporter, OCTN1, to mitochondria. We made GFP- and RFP-human OCTN1 cDNA constructs and showed expression of hOCTN1 in several transfected mammalian cell lines. tema lomba debatWitrynaInteractions between genetic and environmental factors, like exposure to stress, have an important role in the pathogenesis of mood-related psychiatric disorders, such as major depressive disorder. The polyspecific organic cation transporters (OCTs) were shown previously to be sensitive to the stress hormone corticosterone in vitro, suggesting … tema lomba masakWitryna9 cze 2010 · The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver. The excretion of OTA into urine is thought to be mainly by tubular secretion, presumably via the organic anion transport system. Recently, several families of … tema lomba kaligrafi