Cisplatin and kidney injury

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August undefined, 2024

WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … WebDec 2, 2024 · It is well recognized that cisplatin may induce acute kidney injury (AKI) during chemotherapy. However, recent work further indicates that cisplatin treatment may have long-term effects in kidneys resulting in the development or progression of chronic kidney disease (CKD) in treated patients ( 16 ).

The cisplatin-induced acute kidney injury is a novel risk factor for ...

WebRT @NatMetabolism: RESEARCH From Tomohito Doke et al. (@Penn): NMN & NR supplementation has protective effects on kidney injury by preventing cisplatin-induced … WebFeb 18, 2024 · The ability of cisplatin (cis-diamminedichloroplatinum II) toxicity to induce acute kidney injury (AKI) has attracted attention and concern for a long time, but the molecular mechanism of... cincinnati bengals crewneck sweatshirt

Molecular mechanisms of cisplatin-induced nephrotoxicity: a …

WebApr 12, 2024 · Surgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective … WebJan 29, 2024 · Fig. 1: Cisplatin induced Renal injury were alleviated by Ferroptosis inhibitor Ferrostatin-1 (Fer-1). A, B Serum BUN and Cr levels of each group at 48 h and 72 h after cisplatin injection. C... WebMar 20, 2024 · Background The reality of cisplatin-induced acute kidney injury (CIA) and its effects on long-term renal function remain unclear. The aim of this study was to … dhs armhs services

Neferine mitigates cisplatin-induced acute kidney injury in mice …

WebMay 18, 2024 · Vascular injuries caused by cisplatin may be due to an atypical hemolytic uremic syndrome. 58 Renal vascular pathology shows concentric subintimal thickening of small arteries and arterioles, with loose mucoid-appearing material and fibrin thrombi in afferent arterioles and glomerular capillaries. 58 From the age of 18 years to 80 years, … WebNov 1, 2024 · Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a form of... dhs arlington tx cincinnati bengals cowboy boots

"WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. " - Cisplatin and kidney injury

Cisplatin and kidney injury

Cisplatin-induced renal toxicity in elderly people

WebOct 15, 2024 · Cisplatin administration for acute kidney injury (AKI) leads to serious side effects and there is a higher risk of death [2]. In clinical practice, the main causes of AKI are infections, nephrotoxic drugs, diabetes, hypertension, sepsis and cardiovascular disease. WebMay 8, 2024 · Interindividual variability in kidney injury associated with cisplatin is greater than that explained by pharmacokinetic differences among patients. 2 What, if anything, …

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WebA known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates … WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular …

WebOct 14, 2024 · Cisplatin effectiveness is reduced by its dose-limiting nephrotoxicity. Approximately 30% of patients administered cisplatin develop AKI.2There are no … WebThe prevalence of renal diseases including acute kidney injury (AKI) and chronic kidney disease (CKD) is increasing worldwide. However, the pathogenesis of most renal …

WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular … WebApr 14, 2024 · For instance, intraperitoneal nicotinamide improves kidney function in mice with acute kidney injury induced by ischemia/reperfusion or treatment with cisplatin [29 ... . Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury. PLoS ONE 2024, ...

WebThe primary objective was to determine the clinical benefit of mannitol combined with hydration in terms of preventing cisplatin-induced acute kidney injury. The secondary end point was incidence of estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m 2 at 7 days after receiving cisplatin between the two groups.

WebApr 11, 2024 · NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury. Nature Metabolism - Doke et al. show that NMN and … dhs arkansas snap applicationWebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). cincinnati bengals crewneckWebOct 19, 2024 · Background. Few studies describe acute kidney injury (AKI) burden during paediatric cisplatin therapy and post-cisplatin kidney outcomes. We determined risk … cincinnati bengals couchWebSep 2, 2024 · MLT alleviates cellular apoptosis after kidney injury caused by cisplatin, inhibiting the NF-κB–mediated inflammatory response and RIPK1/RIPK3 complex–mediated necroptosis (Kim et al., 2024). Meanwhile, MLT increases the expression of an anti-aging protein, Koltho, and prevents cellular apoptosis, resulting in maintaining the renal ... dhs arpa funding personal care homesWebJan 28, 2024 · A major adverse consequence of cisplatin therapy is acute kidney injury (AKI). It is reported that between 30 and 38 percent of patients develop signs of nephrotoxicity (toxicity in the kidneys) after a single cisplatin dose, despite strategies such as hydration to limit renal exposure. This is problematic for patients as kidney injury can ... dhs ashland wiWebDec 12, 2024 · Cell Death & Disease - PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cells Skip to main content … cincinnati bengals cryingWebMar 27, 2024 · Cisplatin-induced acute kidney injury (AKI) is common during preoperative chemotherapy for esophageal cancer. The purpose of this study was to investigate the association between AKI after preoperative chemotherapy and postoperative complications in patients with esophageal cancer. Methods dhs asbestos wisconsin